منابع مشابه
Diazinon Toxicosis in Geese
On a goose farm with 7600 geese kept in 6 houses, 730 birds in 2 houses died within a single day. After drinking, a certain proportion of geese in the affected houses exhibited trembling, salivation, lachrymation and respiratory distress followed by convulsions, dullness and prostration. The birds died soon after the onset of clinical signs. Postmortem examination revealed the presence of a lar...
متن کاملIn vitro rat hepatic and intestinal metabolism of the organophosphate pesticides chlorpyrifos and diazinon.
Chlorpyrifos (CPF) and diazinon (DZN) are thionophosphorus organophosphate (OP) insecticides; their toxicity is mediated through CYP metabolism to CPF-oxon and DZN-oxon, respectively. Conversely, CYPs also detoxify these OPs to trichloropyridinol (TCP) and 2-isopropyl-4-methyl-6-hydroxypyrimidine (IMHP), respectively. In addition, A-esterase (PON1) metabolism of CPF- and DZN-oxon also forms TCP...
متن کاملShort Communication Human Hepatic Cytochrome P450-Specific Metabolism of the Organophosphorus Pesticides Methyl Parathion and Diazinon
Organophosphorus pesticides (OPs) are a public health concern due to their worldwide use and documented human exposures. Phosphorothioate OPs are metabolized by cytochrome P450s (P450s) through either a dearylation reaction to form an inactive metabolite, or through a desulfuration reaction to form an active oxon metabolite, which is a potent cholinesterase inhibitor. This study investigated th...
متن کاملHuman hepatic cytochrome P450-specific metabolism of the organophosphorus pesticides methyl parathion and diazinon.
Organophosphorus pesticides (OPs) are a public health concern due to their worldwide use and documented human exposures. Phosphorothioate OPs are metabolized by cytochrome P450s (P450s) through either a dearylation reaction to form an inactive metabolite, or through a desulfuration reaction to form an active oxon metabolite, which is a potent cholinesterase inhibitor. This study investigated th...
متن کاملToxicological Profile for Diazinon
The primary purpose of this chapter is to provide public health officials, physicians, toxicologists, and other interested individuals and groups with an overall perspective on the toxicology of diazinon. It contains descriptions and evaluations of toxicological studies and epidemiological investigations and provides conclusions, where possible, on the relevance of toxicity and toxicokinetic da...
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ژورنال
عنوان ژورنال: Journal of Economic Entomology
سال: 1970
ISSN: 1938-291X,0022-0493
DOI: 10.1093/jee/63.3.874